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Itraconazole decreases ergosterol biosynthesis by interfering with cytochrome P450 activity. Itraconazole inhibits cell membrane function of susceptible fungi including Microsporum species, Trichophyton species, Candida species, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatitidis and Paracoccidiodes brasiliensis. Itraconazole also has antiprotozoal activity against Leishmania major.
